PI3K: Downstream AKTion Blocks Apoptosis
نویسندگان
چکیده
منابع مشابه
PI3K: Downstream AKTion Blocks Apoptosis
production of PtdIns-3,4,5-P 3. In vitro, this lipid can be produced by the p170/mCpk-type PI3K that phosphory-Montreal Neurological Institute McGill University lates PtdIns-4-P at the D-3 position (Figure 1) or by a kinase that phosphorylates PtdIns-3-P at the D-4 posi-Montreal, Quebec H3A 2B4 Canada tion (not shown). Thus, the relative levels of PtdIns-3,4-P2 and PtdIns-3,4,5-P3 are independe...
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Akt is a serine-threonine kinase first identified in mice as the cellular homologue of the v-akt oncogene and identified independently as a kinase related to protein kinases A and C.1 As a consequence of the latter discoveries, Akt is also referred to as protein kinase B (PKB). There are three closely related mammalian Akts (Akt1/ PKB , Akt 2/PKB , and Akt 3/PKB ) with similar substrate specifi...
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Inhibition of the mitochondrial pathway of apoptosis has been implicated as a mechanism contributing to carcinogenesis. Chronic inflammation, which is accompanied by activation of inducible nitric oxide synthase and generation of nitric oxide (NO), is associated with cancer development in a variety of gastrointestinal diseases, including cholangiocarcinoma. Therefore, we examined the effects of...
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Members of the fibroblast growth factor receptor (FGFR) family have essential roles in normal physiology and in cancer where they control diverse processes. FGFRs have been associated with breast cancer development. Thus, models to study the role of FGFR in breast cancer and their targeting potential are important. We present an in vitro and in vivo analysis of FGFRs in the breast cancer model ...
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Introduction Thyroid cancer is a malignant disease with poor prognosis. The PI3K/Akt/mTOR and Cyclin-Dependent Kinase 4 (CDK4) pathways are vital regulators of tumor cell proliferation and survival. Therefore the present study was designed to use dual inhibition of such pathways to kill thyroid cancer cells. Methods and materials The effects of each inhibitors on human ATC and...
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ژورنال
عنوان ژورنال: Cell
سال: 1997
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81883-8